Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 1648 0.0 1.0 0.366 0.302
biological_process el 1648 0.0 1.0 0.715 0.43
biological_process ka 1648 0.0 1.0 0.837 0.369
biological_process node2vec 1648 0.0 1.0 0.486 0.374
biological_process rf 1648 0.0 1.0 0.711 0.433
cellular_component ct 1649 0.0 1.0 0.274 0.316
cellular_component el 1649 0.0 1.0 0.292 0.321
cellular_component ka 1649 0.0 1.0 0.578 0.457
cellular_component rf 1649 0.0 1.0 0.276 0.317
disease ct 1461 0.0 1.0 0.313 0.376
disease el 1461 0.0 1.0 0.333 0.454
disease ka 1461 0.0 1.0 0.435 0.493
disease node2vec 1461 0.0 0.997 0.222 0.335
disease rf 1461 0.0 1.0 0.331 0.455
genetic_interaction_weighted ct 1668 0.0 1.0 0.324 0.274
genetic_interaction_weighted el 1668 0.0 1.0 0.336 0.284
genetic_interaction_weighted ka 1668 0.001 1.0 0.813 0.375
genetic_interaction_weighted node2vec 1668 0.0 0.999 0.347 0.294
genetic_interaction_weighted rf 1668 0.0 1.0 0.319 0.282
molecular_function ct 1634 0.0 1.0 0.378 0.361
molecular_function el 1634 0.0 1.0 0.427 0.37
molecular_function ka 1634 0.0 1.0 0.703 0.425
molecular_function rf 1634 0.0 1.0 0.406 0.371
pathway ct 653 0.0 1.0 0.615 0.345
pathway el 653 0.001 1.0 0.775 0.417
pathway ka 653 0.001 1.0 0.795 0.403
pathway node2vec 653 0.0 1.0 0.47 0.349
pathway rf 653 0.001 1.0 0.775 0.417
phenotype ct 1480 0.0 1.0 0.344 0.379
phenotype el 1480 0.0 1.0 0.363 0.467
phenotype ka 1480 0.0 1.0 0.474 0.497
phenotype node2vec 1480 0.0 0.999 0.232 0.331
phenotype rf 1480 0.0 1.0 0.362 0.467
protein_interaction ct 1664 0.0 1.0 0.069 0.165
protein_interaction el 1664 0.0 1.0 0.06 0.148
protein_interaction ka 1664 0.0 1.0 0.305 0.456
protein_interaction node2vec 1664 0.0 0.99 0.126 0.198
protein_interaction rf 1664 0.0 1.0 0.061 0.146

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 1676 0.0 1.0 0.215 0.346
integration_mean_by_presence el 1676 0.0 1.0 0.09 0.205
integration_mean_by_presence ka 1676 0.0 1.0 0.198 0.36
integration_mean_by_presence node2vec 1676 0.0 0.988 0.188 0.283
integration_mean_by_presence rf 1676 0.0 1.0 0.099 0.219
mean ct 1676 0.0 1.0 0.209 0.351
mean el 1676 0.0 1.0 0.073 0.18
mean ka 1676 0.0 1.0 0.196 0.361
mean node2vec 1676 0.0 0.91 0.099 0.189
mean rf 1676 0.0 1.0 0.06 0.146

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels